Department Overview

Findings from the cellular and molecular studies are intended to provide a better understanding about the aetiology and the mechanisms of disease. These findings assist to evaluate the efficacy of preventive, as well as therapeutic, nutritional interventions and eventually lead to more rational strategies for disease prevention and control.

The Cellular and Molecular Nutrition program’s strengths are its emphasis on excellence in translational laboratory research to explore metabolic pathways, gene-nutrient interactions, and mechanisms by which dietary factors influence disease processes, which provide the foundation of the field of Nutrition Science.

Research Centres and Laboratories

These days doing experiments using the cellular and molecular model is very common in the human nutrition research centres. It helps to understand the relationship between nutrition and many diseases by conducting the basic research using cellular and molecular models. Goals: - Determination of the mechanisms of action of nutrients in autoimmune diseases, cancer, obesity and diabetes - To understand of the effect of nutrients on gene expression and details of signalling pathways.

The research that are performed in the laboratory:

1-      Clinical trial of vitamin A supplementation in patients with autoimmune diseases

2-       The effects of vitamin A and D and DHA on animal models of autoimmune diseases

3-       Ex vivo and in vitro studies on cultured of immune cells obtained from autoimmune patients including PBMCs and Neutrophils

4-       Studies on cell transcription factors gene expressions related to Th1, Th2, . Th17, Treg cells

5-      Studies on effects of nutrients on the induction of apoptosis in cancer cells The devices in laboratory includes:

- Incubator Co2 for cell culture

- Laminar hood

- Invert microscope and other equipment needed for sample preparations and handling.

Director: Professor  Mahmoud Jalali.

Faculty Members

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Tehran University of Medical Sciences - School of Nutritional Sciences and Dietetics.